The cozy and welcoming city of Cuenca is the 3rd largest city in Ecuador. You will quickly understand why Cuenca is designated a World Cultural Heritage Site by UNESCO. It is renown for its 17th century colonial architecture and cobblestone streets. Cuenca is known as Santa Ana de los Cuatro Rios de Cuenca or in English Four Rivers of the Santa Ana Cuenca. The streets and shops of Cuenca are filled with artisans creating precious crafts of gold, glass, ceramics and the popular Panama hats, among many others.